Open Computer Use is an agent system that leverages E2B Desktop Sandbox to give AI models control over a remote Linux environment. The agent uses vision models to perceive the display, grounding models for UI element localization, and action models to execute keyboard/mouse inputs and shell commands. It supports swappable LLM providers including Llama 3, Gemini, GPT-4o, Claude, and DeepSeek, with live display streaming and user intervention capabilities.