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microsoft/foldingdiff

A diffusion model for generating novel protein backbone structures using transformer architectures and trigonometric representations.

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Foldingdiff is a deep learning model that learns to generate novel protein backbone conformations through a denoising diffusion process. The model uses attention mechanisms and trigonometric coordinate representations to model the geometry of protein chains. It is trained on the CATH protein structure dataset and provides a pre-trained model via HuggingFace for sampling new structures directly in a browser or locally.

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