QiZhenGPT is an open-source Chinese medical large language model built by instruction-tuning foundation models including Chinese-LLaMA-Plus-7B, CaMA-13B, and ChatGLM-6B on medical datasets derived from the QiZhen medical knowledge base. It improves the model’s performance on Chinese medical Q&A, drug knowledge, disease diagnostics, and related tasks. MedCopilot extends the model into a clinical assistant deployed in Zhejiang University Second Affiliated Hospital.